Only problem i have with gamepad is the R1's Switch feature to get a little stuck if you try to do it too quick. -Also- if you're too eager and still hold down the R1 button after switching to the second set with for example the Circle button, i can push abilities and they wont respond since i'm still holding down the R1 button on mistake... It's not that fun.
Of course Targeting CAN be a hazzle, but also CAN be easier than with mouse! I've tried both and for me, i think Ps3 is formidable since it can target things of importance whereas PC can stray around too much. Oh and you can run in all directions without looking that way. So good for avoiding AoE.