Defragging as much as you do will lower your disk live expectancy (but really just read/write speed) from a few years to 1-2 years. You will definitely notice the drive not copying/deleting as fast as it used to. Accessing the game from the (slightly) speedier part of your HDD is great and all, but it won't make a difference in FPS when game is loaded in memory and access of files is only used to load into new areas. Updating logitech/razer drivers (assuming you have those devices) have nothing to do with performance. If anything those drivers add threads you do not want if your computer is slow enough to benefit from your suggestions. Gamebooster will make a tiny difference on older computers. 120 Hz is amazing and not just for 3D (I hate 3D).

Not trying to nitpick your thread though.. glad people are helping each :P