My story so far...

[MikkoAkure]

This is what Yoshi has said so far for what is coming next:

"Beginning in patch 6.1, this will mark the beginning of an entirely new adventure separate from the Zodiark-Hydaelyn saga,"

"We’re already looking ahead to Patch 6.1 and beyond for the next three years or so, but it’s too early to talk about that now. On the other hand, I can assure you that these new adventures will always be leading on from the ones you’ve been on already. It’s not going to be a story where everyone suddenly gets struck with amnesia, or yet another meteor falls to destroy everything, which would require you to start over. So, for now please look forward to the climax of our first arc!"

"We have no intention of negating all that has happened [in the story]," Yoshida added. "We don't want to negate the adventure that you went on, the characters that you met along the way, and the achievements that you've accomplished throughout your journey. So when we are looking to that transition and moving forward to the next chapter of that story, it's safe to assume that this is still taking place in the same universe so to speak."

I can't find where I saw it, but I'm pretty sure he or someone else also mentioned that this is the last time most of the main characters will have an impactful experience in the story and we'll be saying goodbye to a lot of them (whether dead or otherwise) by the end.

[KizuyaKatogami]

Here’s hoping many of them die off and they give us a new cast of characters to work with. I myself would quite enjoy if they killed off the WoL(us) and maybe had us reincarnate back into a normal adventurer. I don’t have ego issues so i don’t need to go around pretending to be all powerful to make myself feel better. I’d like to just be a normal adventurer exploring new things and whatnot.

[ItMe]

I can't find where I saw it, but I'm pretty sure he or someone else also mentioned that this is the last time most of the main characters will have an impactful experience in the story and we'll be saying goodbye to a lot of them (whether dead or otherwise) by the end.

OH!
I think I know the one you're talking about.
That interview came out... around... the Elidibus arc???
But if I remember right wasn't that revealed to just be a bad translation?