1) I have experienced that. I had trouble moving around on the white staircases, but the Red Girl fight was a whole other level of discomfort. The screen pixellation was jarring enough that I had to look away from the screen to reorient myself. The fight on the flying platform made me seriously motion sick, though fortunately the effect was gone by the time the next boss fight began. Overall, it was extremely unpleasant.

2) Not so far, though I did have the first hints of a migraine the first time I ran it. I logged off immediately. I used to run Copied Factory and Puppets' Bunker during the week because I thought it was fun. I definitely won't be doing that with Tower.

3) n/a

4) n/a