I think it's very unlikely, for the same reason I think it's unlikely that we'll ever run into more fragments of Azem's soul or travel to other reflections: They've already explored the idea pretty well with Shadowbringers, and doing it a second time—whether we're traveling to a new world, the past or future, or a new timeline—would likely just tread the same ground over again. That said, I don't think it's completely out of the question.

And I have to say, the idea of dropping a line like "It's good to see you again, Hades" to Emet-Selch's face tickles my funny bone.