There seems to be a lot of different styles. I considered changing the F1 - F8 to other keys but ultimately that seems like too many keybinds used up on targeting even with the ones it frees up on movement. 8 targets feels like too many for me. It is tempting because this would completely free up the mouse for movement and the mouse is the best way to move is most circumstances. I can see the benefits in pvp as well.

I'm not comfortable with party scroll so I think I'm left with click targeting. I considered mouseovers but I heard they aren't as efficient in FFXIV due to the way macros register spellcasts or something like that. Mouseover macros are a staple to MMORPG healing for sure as well as click-to-cast which I use in WoW. That generally always requires add-ons, which of course there will be none in FFXIV.