If I had to choose between the two, it would have to be Lyse.

As far as I'm concerned Minfillia did nothing but stand behind her desk, tell me that "I must needs return to the Waking Sands" from no matter what side of the planet I'm on, and get kidnapped. Having to put up with her over several alts has only given me a hatred for her shared with no other NPC in this game (save maybe Asahi). My only regret is that I couldn't make my character look completely apathetic (or even celebratory) to her departure.

I much preferred it when Lyse was Yda, however. I've never been a huge fan of the Scions, but the character dynamic Papalymo and Yda had was what made them the most tolerable of the bunch (at least to me). I feel Papalymo's death in retrospect was tragic in that not only did we lose the amusing banter and camaraderie between them, but we lost that playful side of Yda/Lyse that helped her stand out from the others. I understand that having lost her best friend would affect that, but I was hoping she would grow back into it a little over the course of 4.0, you know?