Originally Posted by
Ashkendor
IKR?
In all seriousness, I use: 1-6, Q E R T F G V B, then combinations of various mouse buttons with those. My mouse has four possible buttons to use, one of which is bound to my Push To Talk in my VoIP and one of which I use on its own (scroll wheel). I assigned one to Shift and one to Ctrl in the software for the mouse itself, and I find that I have more than enough space.
Some stuff I still activate by clicking just to make sure I don't fat-finger it or because speed isn't all that important (mounts, etc).