Taking protect off your bar is fine as long as your partner healer keeps it, but it's a pain when someone dies somewhere and you can't get protect back on them. It does have an effect, and if you've ever seen someone survive by a sliver of life (and you should have by this point), that's likely protect in action.
It's already a pain keeping resurrected DPS alive in Susano EX party finders; it doesn't need to be made harder. Similarly swapping Esuna out when you don't need it is fine, but be sure you have it when you need it or there is no excuse. If you want to optimize then make sure you're responsible enough for it.
