I'm accurate with a mouse. Play a lot of FPSes and you will be too.
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With the speed of clicking:
I use a Logitech G500 mouse, so I can have it set to where the arrow flies across my speed with me not even moving the mouse much.
Now onto the targeting stuff:
With the tab-targeting and controllers, I have a lot less accuracy with targeting, personally. (Takes forever, if I hit it one time too many, I have to go through the entire list (or maybe more!) again, hoping I get it right that time, etc.) So I personally do MUCH better with a keyboard+mouse setup, and I spent most of my gaming life using consoles!
And yes, I have used a gamepad. Well, a PS2 controller, anyway. Targeting wasn't as accurate (for me, personally..) as my mouse was in this game. (I use it for XI, though.)
All i know is when i try to target bunched up mobs with a mouse it's just as bad with using tab or w/e