Also the Heavy status. Can't blame your mates for taking avoidable AoE if this is not being cleansed. The reduction to movement is drastic.
Cutters Cry is one early instance I can think of where Esuna is still needed to this day. Chimera is the first boss I can recall that uses non-telegraphed attacks that hit like a truck and also inflict a status ailment. At least one player gets nailed by Dragon/Ram's voice every time I go there, every time they go off. This is also a specific instance I can think of pre-SB that drove me crazy when I was leveling my SCH because I was below level 40 (the previous requirement for Leeches).
I want to say that it isn't until 50+ where the lack of a cleanse can lead to a player KO. Sastasha HM is one that immediately pops in mind.
