Like before a single target might be a bit like:
(Bio) - (Broil for days) / (Ruin if you needed to move) + (Energy Drain for some fae power and ogcd weaving, if you don't need them for heals)
Now:Similar though you'd probably Energy Drain earlier after bio for a faster pustule,
(Bio) - (Energy Drain) - if Pustule (Ruin for extra single target damage) - if outbreak (check bio timer, then Art of War or Energy Drain) - (Broil until pustule or repeat) + (Energy drain weaving when you don't need it for other stuff), the change isn't crazy large but it does add a little of interactive reactivity
AoE:
(Bio) - (Art of War until not worth it) - (Broil till dead after AoE is not worth it, in the unlikely event you need to move maybe use ruin lol)
Now:
(Bio) - (Energy Drain) - (Art of War, standing on the highest priority target) - (Broil pustule, extra aoe damage) - Outbreak effect unlocked, gauge how much bio time is needed and recast if needed - (Art of War outbreak in a central area, causing contagion to spread) - (Art of War) - (Broil, pustule) - (Broil, Pustule) - (Ruin, pustule as 3 or less now are alive) - (Art of War at 3) - (Broil at 2) - (Ruin last pustule appears) - (Broil till dead, probably not worth recasting bio at this point).
Alternatively if you feel like "I don't want to tab target today, I'm tired but I still want to play fairly well" you can run on top of the monster so that your concentric smaller circle overlaps theirs and pop them that way for just a tiny loss compared to broiling them.
Just for fun of making a short tooltip (because the above was long and might seem like "can't be tooltiped", not that mine are great examples lol):
Bio -
Additional Effect: X% chance and increasing each tick to create pustule.
Ruin -
Combo Action: Pustule debuff on target
Combo Potency: ???
Broil -
Combo Action: Pustule debuff on target
Combo Bonus Potency: ??? to all nearby enemies
Energy Drain -
Combo Action: Bio debuff on target
Combo Bonus: Increased chance for a pustule to develop
Combo Action: Outbreak & Bio debuff on target
Combo Bonus Potency: ???
Duration: Time remaining on Bio
Art of War -
Additional Effect: ??% increased damage ?y from center
Combo Action: Pustule debuff on target ?y from center
Combo Potency: ???
Combo Action: Outbreak & Bio debuff on one nearby enemy
Combo Bonus Potency: ???
Duration: Time remaining on Bio
Additional Effect: Ground Zero
Contagion will spread from target, dealing X potency, with a stacking duration based on time remaining of ground zero.