If you've been playing even somewhat often since 4.0 dropped you'll full well know when to use it. Fights in this game are so static I'd hazard a guess that if you've done them more than three times you'll subconsciously know the general flow without even trying to memorize the fight. Granted, you said clicking. Personally, I'm on controller so all I have to do is tap on the d-pad, press the skill and done. I'll admit that it may be a bit more obnoxious with K/M, but for controllers it feels perfect. That said... Most of the time you use it on yourself, so there is no "selecting a target."
