I'm reading the description of TotT (lv15 alchemy ability) on a wiki site and I don't really understand it. I'm assuming it can only be used after "excellent" when the status of a synth turns to "poor". If this was the case it probably wouldn't be all that great as excellent hardly ever appears in my experience (not that I do much crafting mind you).

I'm trying to level a few crafts to 15, then I'll probably try to take this all the way for comfort zone anyway, but just trying to decide which to do first.