I usually put the party frame right above my log against the right margin of the log. Having it closer to the middle will do u a lot of good. Conversely, I have my enmity list on the opposite side of the party list on the right. I find that I really have to sacrifice some of view of what is happening out there to enable your eye and cursor to track quickly. You have to pay attention your party's debuffs constantly so it helps to be front and center. As for tool bars, I have 3 horizontal bars on the bottom. Bar 1 (Healing spells) is 1,2,3,4... Bar 2 (Solo/Targeting mobs) is Ctrl1,C2,C3,C4 Bar 3 (emergency macros and utilities) is Shift1,S2,S3,S4 (this will overwrite the keybind to quick select tool bars). If you want to add a forth u can make it Alt1,A2,A3,A4. 2 Vertical Bars for class switch & pots

I move the XP bar to the bottom and my HP/MP/TP bar up a bit, I dragged my status bar from the top to where my HP bar is then I dont' have to look up at the top all the time.