This goes for any ingame dialogue, FATE, quest, etc, etc.

For me personally, it would have to be that FATE in the Hot Springs when you have to throw "Scarface" out because of his "leering", it's just.. he's a goddamn ixali and the dialogue and everything is just priceless.. xD

Another funny reference is a FATE in Aleport called "The Iron-Contra Affair", I chuckled a bit at that xD..

Also that long quest chain in highbridge with that guy and his hair tonic.. xD The best part is that you get to come back 20 levels later and do it again..