Yes, you should report all of these as soon as you see them. I know first-hand how frustrating it is to report them and see nothing happening, as with the fleece farming bots I've witnessed in Coerthas. However, keep doing it.

The effect this behaviour has on our server economies is devastating and it needs to be stopped. It facilitates RMT money-making and no honest, decent person wants that in FFXIV. Let's get rid of them.