I use only Shift+hotkeys and I don't seem to have this problem. The reason I prefer Shifts over Alts is that there are circumstances where you want to maintain momentum in a certain direction but have to face another direction to cast something or attack something. The only possible way is to jump forward that direction and while midair turn to face another direction to cast and if skill to be casted is an ALT skill, you probably gonna need two thumbs on your left hand to jump and hold ALT at the same time, unless you can press both Alt AND spacebar and roll your thumb over to spacebar after using the ALT hotkey.

If Shifts are used instead of Alts, then it will be much more easier since your pinky can be used together now with your thumb to achieve the midair stunt.