I have never liked the idea of clicking buttons on your screen to activate abilities/skills. Hotkeys are faster, and much more fun and engaging to use compared to simply clicking something.

I have my hotkeys setup like this:

1-5 normal number keys, 6-9 on my mouse, 10-12 on e,c,f keys.

For my other two hotbars its the same except the second hotbar is while holding SHIFT, and the third is while holding CTRL. All easy to execute with my hand.

I also have an extra misc hotbar bound to the Function keys, Q, R, and T for potions, targeting, etc.

I really love the idea of using and pressing so many different keys. It really makes the game so much more engaging and fun at least for me.

Im curious if anyone has a completely different setup and how people on controllers fair for endgame dungeons and the harder content in the game.