This is the first legit "combat flawed" thread I've come across. I know exactly what you mean, its almost an animation lock. For example on my WAR I have a combo I use where I do "Heavy Swing" then "Skull Sunder" and they are tied on cooldown so while that cooldown comes a second time I use "Brutal Swing" as a lead in to "Butcher Block". Even though the cooldown never shows up for "Brutal Swing" I have to wait a few seconds before I can click on it.

This is not a huge deal as long as you are aware of it but a quick "true" global cooldown would be nice. Not something to rage over but something that could be worth bringing to the Dev's attention for future patches or hotfixes.