Im in Australia playing on the NA servers with about 270~ ping. Died once to Titans Geosurge, wasnt aware i was not supposed to go to the edge. Other than that once, i never got hit by anything Titan threw down. In Brayflox, and other bosses who have wide attacks like that, i simply strafe back forth in front of him, not so much to move the boss (easier on large bosses, like the dragon) if no Breath, i scoot back the other way a bit, if there is a breath, i keep moving.

As for interrupts .. I feel like I've only ever gotten an interrupt off when i was paying close attention to the mob i wanted to interrupt, and made plans to do it. And i like that. When tanking, it gives me something to manage, do i have the Enmity lead to give up a combo to stop this spell or should i eat it and trust my healer?