It is still a loss because even spamming a command in a macro to create a pseudo-queue effect will not be as efficient as you queuing up the skills yourself. And this is before we even get into the fact that for 90% of cases, you will not always want to use the same skills after one another every time. E.g. SMN dots, DRG 4th tier procs, BRD procs, RNG in fights that can cause you to need to use a different combo finisher (most obvious for NIN).