Is it a DPS loss to use macros?

[Ossom]

You can actually Queue oGCDs, if you press an oGCD more than half way through your casts, it will go off immediately after the casts finishes. The reason classes can still macro oGCDs is because even then if you're say a brd, mch, or a healer, then you can only get one skill off before your gcd is back up anyways unless you have a proc/swiftcasts. So its fine if the oGCD doesn't go off immediately as long as it doesn't clip the next GCD, which most 1 skill oGCD macros won't do.

[AniCelestine]

You can actually Queue oGCDs, if you press an oGCD more than half way through your casts, it will go off immediately after the casts finishes.

This. The amount of times I've started spamming my aetherflow on sch the moment I started casting my heal, halfway through cast I realise I still have 1 stack left. Proceed to spam ED. I get a full stack of aetherflow and no ED went off, cause my ED used to be macroed.

Also like said on page 2, use macros outside of ffxiv to activate 2 buttons with 1 press if you don't want to keep track of BL/ME works alot better. Though I'm not sure what's SE's stand on this. I've heard some games don't look nicely at you if you do it. So I'd research on this before doing it (personally never needed to use, but I've heard it works like a charm and it makes sense really, since game thinks youre pressing the buttons and not activating the skill via chat log.)