Is it a DPS loss to use macros?

[Wintersandman]

i also was told it's a "dps loss"; however what people don't get about macros is they can't be "queued up" is the problem, and the intervals are in .5 segments so 2.4 is rounded down to 2.0; however 2.5 IS NOT rounded up to 3.0 the combination of "animation lag" and inability to queue up a macro skill

From the testing I have done there is no .5. I have tested with Ninja Mudra's and PLD combo's. There is significantly more delay than me using the buttons myself. As a SMN you don't have to wait for procs but with a lot of other classes you may have to interrupt a combo to use it or completely change targets and thus your queue is wasted.