Is it a DPS loss to use macros?

[Reiterpallasch]

2. The game has the one of the worst gameplay mechanics ever: Animation Lag. Even if you use an ability off the GCD you cannot use another ability immediately afterwards (some abilities may not have enough animation lag to be noticeable but others most definitely do).

There is no "animation lag". You simply cannot use an ability for a short time after specific ones, such as offensive CDs. You can be in the middle of the longest animation in the game and still fire off something like bloodletter in the middle of it with no issues.