Is it a DPS loss to use macros?

[Fori]

2. The game has the one of the worst gameplay mechanics ever: Animation Lag. Even if you use an ability off the GCD you cannot use another ability immediately afterwards (some abilities may not have enough animation lag to be noticeable but others most definitely do). For example, a BLM macro like this:

This pisses me off so bad. One of the only things that makes me not want to play THM. There's nothing more annoying than using thinking you've used Transpose, using a Blizzard 1, only to realise Transpose never went off and you just dispelled your Astral Fire buff, leaving you with no mana and no buff to regen...