I can also see a situation where, if the Cooldown of "Blood of the Dragon" is within 10 seconds and you've just finished up one of your 4th tier combos, let's say "Dragon Tail Sweep", you can blow your "powerful attack" to consume the remaining time and Blood of the Dragoon should become available again just before you apply Chaos/Full thrust to continue looping with a 4th combo.

That, theoretically, is another way to maximise DPS.