I'm working slowly my way towards Titan Hard right now. I can say that on everything up to Amdapor Keep (as well as Dhrome Chimera) I use Jump as long as it is avaiable on cooldown. Every boss has sufficient safe spots, specially if you are on melee range (jump's animation is longer the more distance there is). Just need to know it better.
Trickiest boss to jump on up to now has been Dhorme Chimera because of it's wonky AoEs that are really tricky to dodge, specially when he starts using them instantly. But he has a blind spot in his left side, near his back.