Ok I can't number crunch like some here but after reading through I just want to add some things that popped into my head. For those wondering whether or not it is beneficial to use fracture and phlebotomize, it seems it almost always would be against a boss. In theory its great to string together the absolute highest potency attacks together but in game you rarely get to stand still long enough to do that. So by applying all of your DoTs to the boss you ensure that you are doing some damage even when running from aoe or moving to adds.

Also Im a controller user and managing all these skills is next to impossible without macros. Had to make a macro for combos. One for TT<VT<FT and one for ID<Dis<CT. And one for fracture<phlebotomize. While the macro is going you can still time your off gcd skills in between.