I've also tried to set up my keybindings so that I only have to use the keyboard. I'm having moderate success at this.
I still have to use the mouse to move crap between my retainer and my inventory, mainly because I can't figure out what setting is the one for moving to the next tab of the inventory.
I also have some serious issues with targeting. It seems to want to target the farthest freaking thing from me, unless I rotate the camera a certain way.
I'm probably missing something obvious, but the way they describe some functions in the keybinding settings, it's not always clear what they're referring to ><