I use an Xbox handle on my PC. Hope this helps:
I enabled the CustomizedTargeting Settings found in the Main Menu. I made necessary adjustments. I can't tell you exactly how I set them cause I can't log atm but it explains itself. I have it set up where I can choose to target only Enemies, Party, NCP, or Others. Then, you'll need to use the Directional Button to choose targets(only use DirectionalButton, if you use the "Hold-Down R/LTrigger, SelectTarget per R/LButton" targeting option, the TargetingSystem will still target Pets). I also use my "Lock-on"(Not the lock-on that simply highlights your target) which is the lock-on that keeps your character facing the Targets direction no matter what. So I can run around facing the Target at all times XD)