Quote Originally Posted by Lafaiel View Post
... I macro all the moves I use that are combo'd together with a /wait 1 in between and they go off 100% of the time, the animations for the instant cast skills (for melee since I play warrior and pugilist) are fairly short and that 1 second wait works perfectly unless you have a fairly high latency. Also, hotkey everything you can.
I don't think this addresses the problem. How that macro can help in situations like this: http://www.youtube.com/watch?v=40a_cnDQKeE ?
You have like 1 second to interrupt boss one shot skill, but 1 sec is the time animation plays for your previsous skill, so interrupt won't go off, pretty much a wipe. A tank would be in similar situation if there was an encounter where boss performs special move which one shots tank unless he pops a defensive cooldown. Only difference is - a tank can afford to lose dps, and just stand auto attacking while anticipating that boss move.