So, I've been playing for about one and a half week now and I'm having several questions concerning what I should do when I hit 50.

First of all, I'm planing on learning some crafting Jobs when I hit 50. What are the Jobs that I should consider on getting and leveling?
While browsing through some of the posts here, I noticed that some of you talked about AF2-Equipment, so I was wondering how you'll be able to upgrade your AF-Stuff later on (same story for the Sphairai, since there seems to be a Sphairai+1).

Something else that I need help with is keybinding of skills. I'm having difficulties on finding something that's comfortable for me regarding this issue (for now, I'm going with the standard keybindings and left-clicking on skills if necessary).
Is it better to just write macro's for standard rotations I'll be using, or is it good to change the key-bindings around the WASD-Keys so that I don't have to stretch my hand to it's limits to use one particular skill?