I use keyboard almost exclusively. Only resorting to mouse to target a specific player/mob in a crowd.

wsad to move around.
Then just hit 1-0 to use the skill from the main bar.
Or use ALT+1-0 to use the ALT macros, and likewise CTRL+1-0 to use the control macros.

I also have party members mapped from F1 (top of the list) to F7 (bottom of the list) and F8 (me) (configurable in key bindings).

Super fast and easy to use, never a need to scroll around or move a cursor around to choose what you want. Just hit the key and done.

Also, good practice for the next UI, as it looks like the three hot bars (default, control and shift variations) will all be visible at the same time.