The first option that came to my mind was to add an option to the accessibility section to increase the duration of the orange marker by up to ten seconds. Certainly you can't prevent people abusing that but it would give people with slower reaction times more time to move, there could be an option for extra telegraphs too - Like a rotation marker on San d'Oria third boss. As I said, I know there's no stopping people who don't need those options switching them on but if it helps people who actually need them I don't see the harm.