Like someone above said, Critical failing the very first action (white orb) on a synth you really shouldn't seems to be very common. It's almost like the synth forgets to load your skill levels until the second action or something. Ditto with using abilities as the first action leading to failure. And abilities like Tender Touch and Fulfillment seem to just fail my actions more until they wear off. Then there is the ~1:5 synths that experience the downward spiral effect where one failed action seems to trigger a chain reaction of failed actions until you've lost 7 in a row and blown up before 50%. Maybe this is all in my head and just bad luck from the random number generator, but these things seem common enough to me.