We basically already have this. There is 4 true types of mitigation of which 2 act exactly the same in all circumstances
1) shields- their unique characteristic is shield cheesing where if you take zero damage because it was entirely absorbed by the shield you can avoid some negative debuffs
2) increased damage resistance (eg sacred soil) or
3) reduce damage dealt by boss (eg disassemble)- these two always act exactly the same in all instances and their unique characteristic is that they snapshot reduced damage for flow on effects like DOT busters while shields don’t (not 2 and 3 do actually have one point of difference. 3 doesn’t work if the boss isn’t the origin of the damage)
4) true invulns (HG and SB)- mostly just flavour here but they technically can erase certain debuffs due to taking zero damage like shield cheesing (the big example I can think of is queens doom tankbuster in DRN/S)
If you want to snapshot reduced damage for flow on effects use mitigation, if you want to shield cheese debuffs or increase max HP (which can also overcome HP based damage like evens gravity) use shields