Currently running 5e...

Totes truthsies, whether or not I pick up the system is dependent on whether or not my whole group does, and whether or not it addresses the balance issues between martials and casters. Ideally the Armory System will be included in some capacity so you aren't locked into a single class and can change up your party makeup on the fly to adapt to different situations, but I really hope there's some effort to keep casters and martials in relative parity.

Of course, even if they do so, TTRPGers are infamous for hating any effort to keep casters in check, so who knows.

Really though, as just a system you could use it for anything. Even not on Etheirys.