So, I have to play on controller due to my disability. I also use toggle mode for the triggers because of that, so I can't use the W crossbar.

Anyway, I have two combat hotbars. Hotbar 1 is single target, hotbar 2 is AoE. Important abilities (like combos) are on the face buttons so I can press them while moving. I also tend to arrange them as a tree, with the root at the bottom.

Samurai example w/ PS4 controller:

R2 -
X: Hakaze
[]: Jinpu
/\: Gekko
O: Shifu

L2 -
X: Yukikaze
O: Kasha

With the D-pad, I put important/more used abilities on right and down because they're easier for me to hit with my left thumb. I can place my thumb on the left stick easier with them than left or up.

I also want to take this time to thank the devs for how good the controller support is. Without it, I literally wouldn't be able to play this game. Instead, I've been playing since ARR.