I actually use both mouse and keyboard movement somewhat simultaneously depending on what's happening. A side note that I'm mousing with my left hand, right hand on WASD.
For the most part, I use WASD for movement and mouse for steering with Q and E still bound to turn left/right as needed. If I'm doing actions whilst on the move, I'll switch to both mouse buttons to move whilst steering with the mouse as well to free my right hand for party selection/hotkeys as needed. If I'm using the mouse to drop an asylum/Lily in a specific spot I can still steer myself in a pinch whilst moving as normal with the keys alone. One thing to note as well is that I use Standard Type movement and have had to pick up a few quirks such as hopping whilst casting on the move to avoid myself getting spun the wrong way as well as backpedaling like a crab (WoW PvP taught me that one).
If you can train yourself to use multiple movement methods interchangeably, that's a useful card to have up your sleeve.