From the looks of it, it looks like a couple filler combos with a 2 step Toxicon combo system being proposed. I am assuming the Dosis Dot will be dropped to allow for SCH differences? Or is it a combo bonus now? Right now, I am on my phone, so I may need to correct some things later on double checking the combos desired.

Dosis > E! Dosis > Modified Dyskrasia
Addersting is granted at the end
Repeat combo a 2nd time
E! Toxicon > Toxicon
Revert back to beginning

Aoe is similar except it uses this filler combo instead

Dyskrasia > E! Dyskrasia >Modified Dosis
Addersting is granted at the end as usual

The Phlegma would obviously be slotted in before each combo. Just focusing on the changes proposed.

If we are keeping the E! Prognosis Addersting generation or using Rhizomata, the combos could just be used once and then we go straight into the Toxicon combo.

For the Physis and Holos change, will it still retain the Hot and other effects they already have? Did you just want them to also damage the enemies within range too?