The big event at the end of the current patchcycle - Predictions

[RyuDragnier]

My expectation at the moment is that the big event will end up being something a lot less grand (personally I wonder if they'll do a character death). Personally I fully expect the Golbez stuff to be fully stand alone and likely be fully tied up in 6.4

Yoshi-P had said the current arc had nothing to do with where we're going next, so you're likely correct. It might however give Y'shtola an idea for how to reach the First, thus "writing her off" as she goes all in on mastering the ability to travel across shards (which will likely come up in another expansion) and not travel with us to the next expansion areas.