Make sure to keep up-to-date on your gear, especially your tools. It feels like it makes a lot bigger difference than it used to. Aside from that, use abilities that guarantee success (Maker's Muse is very good, it's low level Blacksmith) and make sure to use Wait if the orb isn't yellow or white. Red and Rainbow have lower success rates.

Don't forget to throw in a few Careful Synthesis actions in so you get a larger quality bonus, too.