Given that you'd need over 64GB of RAM, which on any dual channel platform puts you at 128GB given how you buy RAM modules, you'd also have to be on a CPU/motherboard platform that's really new. You'd remove any storage bottleneck long before running it entirely from RAM. Even a SATA SSD pretty much removes all storage bottlenecks this game has. It wouldn't be very interesting beyond doing an LTT-style clickbait YouTube video and thumbnail.