Quote Originally Posted by Rongway View Post
There is a separate keybind for that: Target Nearest Enemy. It's appropriate for them to be two separate keys so that you can always choose to target the nearest enemy regardless of what you are targeting and where its placement in a group or on the screen is.

Target Nearest Enemy and Target Nearest NPC or Object are two of the most useful keybinds in the game and everyone should map them to something close to resting position because you will press them a lot.
+1
I have it set so I press "enter" to target the nearest thing, then just SHIFT+up/down to go up/down the party list and left/right to go through the nearest mobs/NPCs.

Any more complicated than that and I can just use the mouse, but honestly I have never really needed to in 10ish years playing.