Honestly, if you are using an MMO mouse, with shift, ctrl and or alt, you should be able to manage 36-48 keybinds quite comfortably really, and that's not including using the keyboard for easy to reach buttons. Personally only use ctrl and shift as modifiers, and can fit every action for every job on hotbars without issue. Might be that you may need to organise your hotbars a bit better.

Some actions upgrade into different actions, like Berserk into Inner Release, Inner Beast into Fell Cleave and Steel Cyclone into Decimate.