Look at the garbage I put myself through to learn my opener.

[Floortank]

They've got a pretty smart layout for the thumb keys on a mouse. It'd be a lot worse to try and do that rotation on every normal number key as they're laid out on the keyboard, much less the F-keys.

I do think the placement of Shinten and Shoha are gonna cause them "fat finger" issues though. Since they have to cross over weaponskill keys to hit them. Probably better to keep principle GCDs to oneside and abilities to another for the purpose of double weaving.

EDIT:

OP, I rearranged it to show you the way I do it with a reduced mouse key structure. Also I moved your Senei and Shoha to where I do them in the opener.