For anything like standard combos or rotation stuff:
1 2 3 4 and alt+1 2 3 4
These are the only hotkeys that are quick and easy for me to hit in combat. Naked 5 is a very niche maybe, the alt+ version is right out the window. I'll still put some other stuff on the 90-= side that's not time-sensitive where I don't mind clicking for it. If a job really truly requires more than that, well... something(probably utility or side-combo WSs) is never going on the hotbars and will be treated as if it doesn't exist.