I'd like to see in conjunction with the new toggleable all/party/friendly/enemy system.
The ability to [tab] to nearest target to cursor.

I've long been a Fan of [tab] quick select on mobs/players, especially when it's coupled with the mouse hovering over, or near your target.
No effort at all required to roll the finger onto the 1 key to fire off your first skill once you've positively selected the target you want.
Instead of having to scroll though several other potential targets till you get the one your after.