As far as deaths amongst the Scions are concerned I think Y'shtola would be an excellent candidate. Or perhaps Alisae. Both of them are rather reckless and I think it'd make for a touching story to show how arrogance, hubris and complacency can lead to tragedy.

It'd also pave the way for some new characters to stand front and centre who are designed to appeal to a broader variety of tastes instead of being yet another scholar originating from Sharlayan with the exact same beliefs and opinions on practically every matter of note.